A Clinician’s Handbook for Childhood & Adult Immunizations in Georgia

Pediarix® DTaP / Hep B / IPV

Pathophysiology

(See DTaP, Hepatitis B, and IPV pages)

Vaccine Description

Combined diphtheria and tetanus toxoids and acellular pertussis adsorbed (DTaP), Hepatitis B recombinant (Hep B), and inactivated polio virus vaccine (IPV).

Dose & Route

0.5 ml given IM

Administration Schedule

*Pediarix may only be used in children younger than age 7

Dose        Recommended Age

Dose 1…..2 months
Dose 2…..4 months
Dose 3…..6 months

Booster Doses

Pediarix® cannot be used for booster doses. The DTaP series (doses #4 and #5) and the IPV series (dose #4) must be completed with single antigen vaccines

Minimum Intervals

Dose       Minimum Interval and Ages

Dose 1….6 weeks of age
Dose 2….4 weeks after dose 1 (10 weeks of age)
Dose 3….8 weeks after dose 2 and 16 weeks after dose 1 and at least 24 weeks of age

Contraindications

  • Anaphylactic reaction following a prior dose of Pediarix® or any of its component vaccines.
  • Hypersensitivity to any component of the vaccine including yeast, neomycin and polymyxin B.
  • History of encephalopathy within 7 days of a previous dose of any pertussis-containing vaccines.
  • Progressive neurologic disorder, including infantile spasms, uncontrolled epilepsy or progressive encephalopathy.
  • Guillain-Barre` syndrome (GBS) within 6 weeks after a previous dose of tetanus toxoid-containing vaccine.

Precautions

  • Defer vaccination in children with moderate or severe acute illness until illness subsides.
  • Precautions applying to any of the component vaccines.
  • Latex sensitivity

Special Instructions

  • ACIP continues to recommend the birth dose of single antigen Hep B vaccine and has approved Pediarix™ to complete the Hep B series regardless of the mother’s HBsAg status, provided the minimal age and time intervals for Hep B are observed.
  • It is permissible to administer 4 doses of hepatitis B vaccine when Pediarix is used following a birth dose of hepatitis B vaccine. However, a dose of Hepatitis B vaccine must be administered on or after 24 weeks of age.
  • Pediarix™ may be given simultaneously with any other vaccine(s) at separate sites.
  • Pediarix™ can be used interchangeably if necessary with single antigen components (DTaP, IPV, Hep B) as long as minimal ages and intervals are observed.
Download - Pediarix® DTap/Hep B/IPV Pdf